Key question!


ASK: how often do you suffer from heartburn each week?


Twice or more per week = frequent heartburn

Break the cycle of short-term
relief with Nexium Control

The short-term relief cycle

Antacids and alginates only offer short term relief from the pain of occasional heartburn, neutralising the acid in the stomach for a few hours until the stomach empties. At this point more acid is produced and the cycle starts again.

Break the cycle

Nexium Control reduces the production of stomach acid for 24-hour protection, treating the cause of heartburn and allowing time for the oesophagus to recover from the acid irritation.

Nexium Control, the UK’s No 1 for 24-hour heartburn protection1

A first line recommendation
for frequent heartburn

NICE guidelines recommend PPI’s, such as Nexium Control,
as first line treatment for frequent heartburn2

Nexium Control Packs
1 pill a day | For 24 hour protection | For zero heartburn

Nexium Control easy to swallow mini capsules: 53% smaller than tablets*

With just one pill a day, Nexium Control makes the difference for frequent heartburn sufferers

8 out of 10 image

8 out of 10 people
reported first resolution within the
first week of treatment

4 out of 5 image

4 out of 5 nights
were heartburn free

Access additional information and
tools for you and your team

* Based on volume of tablet vs capsule

  1. Nielsen Scantrack. Total Coverage, L12W unit sales WE 05.09.20
  2. NICE Guidelines CG184 Sept 2014. Available at Accessed 14/9/20


Product Information

Name of product: Nexium Control 20 mg gastro resistant tablets and hard capsules

Active ingredient: Esomeprazole

Product licence numbers: EU/1/13/860/001; EU/1/13/860/002 and EU/1/13/860/003

Name and address of the product licence holder: Pfizer Healthcare Ireland, 9 Riverwalk, National Digital Park, Citywest Business Campus, Dublin 24, D24 NT20

Supply classification: General Sales List (GSL)

Indications: The short term treatment of reflux symptoms (e.g. heartburn and acid regurgitation) in adults.

Side Effects: Common: headache, abdominal pain, constipation, diarrhoea, flatulence, nausea/ vomiting, fundic gland polyps (benign). Uncommon: peripheral oedema, insomnia, dizziness, paraesthesia, somnolence, vertigo, dry mouth, increased liver enzymes, dermatitis, pruritus, rash urticaria. Rare: leukopenia, thrombocytopenia, hypersensitivity reactions e.g. fever, angioedema and anaphylactic reaction/shock, hyponatraemia, agitation, confusion, depression, taste disturbance, blurred vision, bronchospasm, stomatitis, gastrointestinal candidiasis, hepatitis with or without jaundice, alopecia, photosensitivity, arthralgia, myalgia, malaise, increased sweating. Very rare: agranulocytosis, pancytopenia, aggression, hallucinations, hepatic failure, hepatic encephalopathy in patients with pre-existing liver disease, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN), muscular weakness, interstitial nephritis, gynaecomastia. Not known: hypomagnesaemia; severe hypomagnesaemia can correlate with hypocalcaemia; hypomagnesaemia may also result in hypokalaemia, microscopic colitis, subacute cutaneous lupus erythematosus (SCLE).

Precautions: Patients should be instructed to consult a doctor if: They have significant unintentional weight loss, recurrent vomiting, dysphagia, haematemesis or melaena and when gastric ulcer is suspected or present, malignancy should be excluded as treatment with esomeprazole may alleviate symptoms and delay diagnosis. They have had previous gastric ulcer or gastrointestinal surgery. They have been on continuous symptomatic treatment of indigestion or heartburn for 4 or more weeks. They have jaundice or severe liver disease. They are aged over 55 years with new or recently changed symptoms. Patients with long term recurrent symptoms of indigestion or heartburn should see their doctor at regular intervals. Patients over 55 years taking any non prescription indigestion or heartburn remedy on a daily basis should inform their pharmacist or doctor. Patients should not take Nexium Control as a long term preventive medicinal product. Treatment with proton pump inhibitors (PPIs) may lead to a slightly increased risk of gastrointestinal infections such as Salmonella and Campylobacter and in hospitalised patients, also possibly Clostridium difficile. Patients should consult their doctor before taking this medicinal product if they are due to have an endoscopy or urea breath test. Co administration of esomeprazole with atazanavir is not recommended. If the combination of atazanavir with a PPI is judged unavoidable, close clinical monitoring is recommended in combination with an increase in the dose of atazanavir to 400 mg with 100 mg of ritonavir. Esomeprazole 20 mg should not be exceeded. Esomeprazole is a CYP2C19 inhibitor. When starting or ending treatment with esomeprazole, the potential for interactions with medicinal products metabolised through CYP2C19 should be considered. An interaction is observed between clopidogrel and esomeprazole. The clinical relevance of this interaction is uncertain. The use of esomeprazole with clopidogrel should be discouraged. Patients should not take another PPI or H2 antagonist concomitantly. Increased Chromogranin A (CgA) level may interfere with investigations for neuroendocrine tumours. To avoid this interference, Nexium Control treatment should be stopped for at least 5 days before CgA measurements. If CgA and gastrin levels have not returned to reference range after initial measurement, measurements should be repeated 14 days after cessation of PPI treatment. Proton pump inhibitors are associated with very infrequent cases of SCLE. If lesions occur, especially in sun-exposed areas of the skin, and if accompanied by arthralgia, the patient should seek medical help promptly and the health care professional should consider stopping Nexium Control. SCLE after previous treatment with a proton pump inhibitor may increase the risk of SCLE with other proton pump inhibitors. This medicinal product contains sugar spheres (sucrose). Patients with rare hereditary problems of fructose intolerance, glucose galactose malabsorption or sucrase isomaltase insufficiency should not take this medicinal product.

Contra-indications: Hypersensitivity to the active substance, substituted benzimidazoles or to any of the excipients. Esomeprazole must not be used concomitantly with nelfinavir.

Dosage and Method of use: The recommended dose is 20 mg esomeprazole (one tablet or capsule) per day. It might be necessary to take the tablets or capsules for 23 consecutive days to achieve improvement of symptoms. The duration of treatment is up to 2 weeks. Once complete relief of symptoms has occurred, treatment should be discontinued. If no symptom relief is obtained within 2 weeks of continuous treatment, the patient should be instructed to consult a doctor. Dose adjustment is not required in patients with impaired renal function. Due to limited experience in patients with severe renal insufficiency, such patients should be treated with caution. Dose adjustment is not required in patients with mild to moderate liver impairment. However, patients with severe liver impairment should be advised by a doctor before taking Nexium Control. Dose adjustment is not required in elderly patients. There is no relevant use of Nexium Control in the paediatric population below 18 years of age for the indication of “short-term treatment of reflux symptoms (e.g., heartburn and acid regurgitation)”. The tablets should be swallowed whole with half a glass of water. The tablets must not be chewed or crushed. Alternatively, the tablet can be dispersed in half a glass of non carbonated water. No other liquids should be used as the enteric coating may be dissolved. The water should be stirred until the tablet disintegrates. The liquid with the pellets should be drunk immediately or within 30 minutes. The glass should be rinsed with half a glass of water and the water drunk. The pellets should not be chewed or crushed. The capsules should be swallowed whole with half a glass of water. The capsules must not be chewed, crushed or opened.

Cost: Pack of 7 tablets RRP £6.99, pack of 14 tablets RRP £11.99. Pack of 14 capsules RRP £12.99. The prices include VAT.

Date: October 2018